Article
IL-1β, IL-10 and TNF-α polymorphisms may affect systemic lupus erythematosus risk and phenotype.
Clinical and experimental rheumatology - 1 Sept 2022
Rzeszotarska Ewa, Sowinska Anna, Stypinska Barbara, Lutkowska Anna, Felis-Giemza Anna, Olesinska Marzena, Puszczewicz Mariusz, Majewski Dominik, Jagodzinski Pawel Piotr, Haładyj Ewa, Paradowska-Gorycka Agnieszka
Abstract excerpt
OBJECTIVES: Systemic lupus erythematosus (SLE) is an autoimmune disease, and IL-1β, IL-10, and TNF-α genes are important in the pathogenesis of this disease. We studied the impact of IL-1β-511, IL-1β +3953, IL-10 -592, IL-10 -1082, TNF-α -308, TNF-α -238, and TNF-α +489 polymorphisms on SLE risk and phenotype in SLE patients and healthy controls. METHODS: We genotyped SLE patients and healthy controls by...
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