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Article

Anticipating resistance to KRAS inhibition: a novel role for USP21 in macropinocytosis regulation.

Genes & development - 1 Oct 2021

Crawford Howard C

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Virtually all PDAC harbors an oncogenic mutation in the KRAS gene, making it the prime target for therapy. Most previous attempts to inhibit KRAS directly have been disappointing, but recent success in targeting some KRAS mutants presages a new era in PDAC therapy. Models of PDAC have predicted that identifying KRAS inhibitor resistance...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34599002
DOI: 10.1101/gad.348971.121
PMCID: PMC8494204

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