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Article

Novel selective inhibitors of macropinocytosis-dependent growth in pancreatic ductal carcinoma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Aug 2024

Brambillasca Silvia, Cera Maria Rosaria, Andronache Adrian, Dey Sumit Kumar, Fagá Giovanni, Fancelli Daniele, Frittoli Emanuela, Pasi Maurizio, Robusto Michela, Varasi Mario, Scita Giorgio, Mercurio Ciro

Abstract excerpt

Macropinocytosis is a cellular process that enables cells to engulf extracellular material, such as nutrients, growth factors, and even whole cells. It is involved in several physiological functions as well as pathological conditions. In cancer cells, macropinocytosis plays a crucial role in promoting tumor growth and survival under nutrient-limited conditions. In particular KRAS mutations have been identified as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38906021
DOI: 10.1016/j.biopha.2024.116991
PMCID: PMC11287759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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