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Article

KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.

PloS one - 1 Jan 2022

Rudd Meghan L, Hansen Nancy F, Zhang Xiaolu, Urick Mary Ellen, Zhang Suiyuan, Merino Maria J, Mullikin James C, Brody Lawrence C, Bell Daphne W

Abstract excerpt

Endometrioid endometrial carcinomas (EECs) are the most common histological subtype of uterine cancer. Late-stage disease is an adverse prognosticator for EEC. The purpose of this study was to analyze EEC exome mutation data to identify late-stage-specific statistically significantly mutated genes (SMGs), which represent candidate driver genes potentially associated with disease progression. We exome sequenced 15...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35081118
DOI: 10.1371/journal.pone.0251286
PMCID: PMC8791453

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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