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Article

Comprehensive molecular characterization of early stage grade 3 endometrioid endometrial adenocarcinoma.

Gynecologic oncology - 1 Oct 2024

Cun Han T, Bernard Laurence, Lande Karin Teien, Lawson Barrett C, Nesbakken Anne-Jorunn, Davidson Ben, Lindemann Kristina, Fellman Bryan, Sørlie Therese, Soliman Pamela T, Eriksson Ane Gerda Zahl

Abstract excerpt

OBJECTIVE: The treatment for stage IB grade 3 endometrioid endometrial adenocarcinoma is challenging with variable practice. Molecular characterization may help identify adjuvant therapy strategies beyond stage. We aimed to better understand the molecular features of these tumors by characterizing them by ProMisE classification, mutational signature, and commonly mutated genes. METHODS: Patients with stage IB...

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Topics

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Share to Carcinoma, Endometrioid
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase II

Share to Endometrial Neoplasms

Share to Neoplasm Grading

Share to Neoplasm Recurrence, Local

Share to Poly-ADP-Ribose Binding Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 39126895
DOI: 10.1016/j.ygyno.2024.07.677
PMCID: PMC11660112

Genes

POLE
ARID1A
MUC16
PIK3CA
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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