Article
Coding and regulatory variants are associated with serum protein levels and disease.
Nature communications - 25 Jan 2022
Emilsson Valur, Gudmundsdottir Valborg, Gudjonsson Alexander, Jonmundsson Thorarinn, Jonsson Brynjolfur G, Karim Mohd A, Ilkov Marjan, Staley James R, Gudmundsson Elias F, Launer Lenore J, Lindeman Jan H, Morton Nicholas M, Aspelund Thor, Lamb John R, Jennings Lori L, Gudnason Vilmundur
Abstract excerpt
Circulating proteins can be used to diagnose and predict disease-related outcomes. A deep serum proteome survey recently revealed close associations between serum protein networks and common disease. In the current study, 54,469 low-frequency and common exome-array variants were compared to 4782 protein measurements in the serum of 5343 individuals from the AGES Reykjavik cohort. This analysis identifies a large...
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