Article
Co-regulatory networks of human serum proteins link genetics to disease.
Science (New York, N.Y.) - 24 Aug 2018
Emilsson Valur, Ilkov Marjan, Lamb John R, Finkel Nancy, Gudmundsson Elias F, Pitts Rebecca, Hoover Heather, Gudmundsdottir Valborg, Horman Shane R, Aspelund Thor, Shu Le, Trifonov Vladimir, Sigurdsson Sigurdur, Manolescu Andrei, Zhu Jun, Olafsson Örn, Jakobsdottir Johanna, Lesley Scott A, To Jeremy, Zhang Jia, Harris Tamara B, Launer Lenore J, Zhang Bin, Eiriksdottir Gudny, Yang Xia, Orth Anthony P, Jennings Lori L, Gudnason Vilmundur
Abstract excerpt
Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were measured in the serum of 5457 Icelanders over 65 years of age. Pairwise correlation between proteins as they varied across individuals revealed 27 different network modules of serum proteins,...
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