Article
Structural and functional impact by SARS-CoV-2 Omicron spike mutations.
Cell reports - 26 Apr 2022
Zhang Jun, Cai Yongfei, Lavine Christy L, Peng Hanqin, Zhu Haisun, Anand Krishna, Tong Pei, Gautam Avneesh, Mayer Megan L, Rits-Volloch Sophia, Wang Shaowei, Sliz Piotr, Wesemann Duane R, Yang Wei, Seaman Michael S, Lu Jianming, Xiao Tianshu, Chen Bing
Abstract excerpt
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), bearing an unusually high number of mutations, has become a dominant strain in many countries within several weeks. We report here structural, functional, and antigenic properties of its full-length spike (S) protein with a native sequence in comparison with those of previously prevalent variants. Omicron S requires a...
Topics
- COVID-19
- Humans
- Mutation
- SARS-CoV-2
- Spike Glycoprotein, Coronavirus