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Article

Impact of miRNA-binding site polymorphisms in STAT3 gene on occurrence and clinical characteristics of systemic lupus erythematosus.

Lupus - 1 Mar 2022

Salehi Amirhossein, Nasrollahzadeh Sabet Mehrdad, Esmaeilzadeh Emran, Mousavi Maryam, Karimi Jalal, Pakzad Bahram

Abstract excerpt

BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is a major regulator of immune response and chronic inflammatory conditions acting through regulation of B cells, T-helper 17 (Th17) cells, and IL-17 production. Previous studies have demonstrated that dysregulation of STAT3 is crucial for SLE pathogenesis and disease severity. It is believed that single nucleotide polymorphisms (SNPs) located...

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PMID: 35073195
DOI: 10.1177/09612033221076739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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