Effect of rs1058240 polymorphism in 3'-UTR of GATA3 gene on potential binding of miRNAs and its association with RRMS risk: bioinformatics analysis and case-control study.

doi:10.1080/00207454.2023.2272043

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Article

Effect of rs1058240 polymorphism in 3'-UTR of GATA3 gene on potential binding of miRNAs and its association with RRMS risk: bioinformatics analysis and case-control study.

The International journal of neuroscience - 1 Dec 2024

Anarlouei Shirin, Roohy Fatemeh, Mohamadynejad Parisa

Abstract excerpt

AIM: Multiple sclerosis is believed to be an autoimmune disease that is influenced by T helper (Th) cell differentiation. GATA3 plays an important role in reducing the development and severity of MS by shifting the differentiation of Th cells to Th2 and regulatory T cells while inhibiting the differentiation of Th1 and Th17 cells. Considering the functional role of rs1058240 SNP in the 3'-UTR of GATA3 mRNA, the...

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PMID: 37842852
DOI: 10.1080/00207454.2023.2272043

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