Article
Association of a miRNA-binding site polymorphism in IL-16 gene with disease risk and clinical characteristics of rheumatoid arthritis and systemic lupus erythematosus.
Clinical rheumatology - 1 Jul 2022
Zeinalzadeh Somayeh, Kheradmand Nahid, Rasouli Ghazal, Esmaeilzadeh Emran, Pakzad Bahram, Behroozi Javad, Chamanara Mohsen, Zoshk Mojtaba Yousefi, Ehtesham Naeim, Sabet Mehrdad Nasrollahzadeh
Abstract excerpt
INTRODUCTION: /objectives. Single nucleotide polymorphisms (SNPs) located at the 3'-UTR region of the target genes of microRNAs (miRNAs) can dysregulate their expression via disrupting the binding site of miRNAs. Interleukin-16 (IL-16) is involved in the pathogenesis of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In the current study, we assessed the possible association between rs1131445...
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