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Article

Three functional variants in the NLRP3 gene are associated with susceptibility and clinical characteristics of systemic lupus erythematosus.

Lupus - 1 Jul 2021

Ehtesham Naeim, Zare Rafie Maryam, Esmaeilzadeh Emran, Dehani Mohammad, Davar Saeideh, Mosallaei Meysam, Pakzad Bahram, Ghorashi Tahereh, Darvish Hossein, Soosanabadi Mohsen

Abstract excerpt

OBJECTIVE: Nod-like receptor pyrin domain containing 3 (NLRP3) gene encodes an intracellular receptor whose dysregulation in systemic lupus erythematosus (SLE) has been reported in multiple studies. Activation of NLRP3 inflammasome leads to the induction of inflammatory response via cleaving and producing of specific cytokines. In the present study, we assessed the possible association between three functional...

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PMID: 33951966
DOI: 10.1177/09612033211014273

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