Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fate of hematopoietic stem cells determined by Notch1 signaling (Review)

27 Dec 2021

Abstract excerpt

Regulation of the fate of hematopoietic stem cells (HSCs), including silencing, self-renewal or differentiation into blood line cells, is crucial to maintain the homeostasis of the human blood system and prevent leukemia. Notch1, a key receptor in the Notch signaling pathway, plays an important regulatory role in these properties of HSCs, particularly in the maintenance of the stemness of HSCs. In recent decades,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Hematopoietic Stem Cell Transplantation
Share to Mesenchymal stem cell research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35069851
DOI: 10.3892/etm.2021.11093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fate of hematopoietic stem cells determined by Notch1 signaling (Review)PMID 35069851Read ↗

Cellular and Molecular Mechanisms Involved in Hematopoietic Stem Cell Aging as a Clinical ProspectSemantic proximity Read ↗

Notch signaling in development and disease.Semantic proximity Read ↗

The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.Semantic proximity Read ↗

Role of HDACs in normal and malignant hematopoiesisSemantic proximity Read ↗

[The role and research progress of NOTCH1 in T-cell acute lymphoblastic leukemia].Semantic proximity Read ↗

Hematopoietic stem cells: self-renewal and expansionSemantic proximity Read ↗

The consensus on indications, conditioning regimen, and donor selection of allogeneic hematopoietic cell transplantation for hematological diseases in China—recommendations from the Chinese Society of HematologySemantic proximity Read ↗

Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cellsSemantic proximity Read ↗

Progress in research on childhood T-cell acute lymphocytic leukemia, Notch1 signaling pathway, and its inhibitors: A reviewSemantic proximity Read ↗

Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation.Semantic proximity Read ↗

Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcomeSemantic proximity Read ↗

The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.