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Article

Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120.

Molecular pharmacology - 1 May 2016

Prihandoko Rudi, Alvarez-Curto Elisa, Hudson Brian D, Butcher Adrian J, Ulven Trond, Miller Ashley M, Tobin Andrew B, Milligan Graeme

Abstract excerpt

It is established that long-chain free fatty acids includingω-3 fatty acids mediate an array of biologic responses through members of the free fatty acid (FFA) receptor family, which includes FFA4. However, the signaling mechanisms and modes of regulation of this receptor class remain unclear. Here, we employed mass spectrometry to determine that phosphorylation of mouse (m)FFAR4 occurs at five serine and...

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Source

Identifiers

PMID: 26873857
DOI: 10.1124/mol.115.101949

Genes

FFAR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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