Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-7 and soluble Interleukin-7 receptor levels in type 1 diabetes - Impact of IL7RA polymorphisms, HLA risk genotypes and clinical features.

Clinical immunology (Orlando, Fla.) - 1 Feb 2022

Hoffmann Maximilian, Enczmann Jürgen, Balz Vera, Kummer Sebastian, Reinauer Christina, Döing Carsten, Förtsch Katharina, Welters Alena, Kohns Vasconcelos Malte, Mayatepek Ertan, Meissner Thomas, Jacobsen Marc, Seyfarth Julia

Abstract excerpt

High soluble IL-7 receptor (sIL-7R) serum levels and associated single nucleotide polymorphisms in the IL7RA gene were found in autoimmune diseases including type 1 diabetes. Further determinants on sIL-7R and IL-7 availability as well as changes during type 1 diabetes disease course remain elusive. Here we performed multiparameter analysis to identify influential genetic and disease-associated factors on sIL-7R...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Haplotypes

Share to Histocompatibility Antigens Class I

Share to Interleukin-7

Share to Polymorphism, Genetic

Share to Receptors, Interleukin-7

Source

Identifiers

PMID: 35063672
DOI: 10.1016/j.clim.2022.108928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-7 and soluble Interleukin-7 receptor levels in type 1 diabetes - Impact of IL7RA polymorphisms, HLA risk genotypes and clinical features.PMID 35063672Read ↗

Interleukin-7 receptor α-chain haplotypes differentially affect soluble IL-7 receptor and IL-7 serum concentrations in children with type 1 diabetes.Semantic proximity Read ↗

Concentration and activity of the soluble form of the interleukin-7 receptor α in type 1 diabetes identifies an interplay between hyperglycemia and immune function.Semantic proximity Read ↗

IL7RA genetic variants differentially affect IL-7Rα expression and alternative splicing: a role in autoimmune and infectious diseases?Semantic proximity Read ↗

IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis.Semantic proximity Read ↗

Interleukin-7: Fuel for the autoimmune attack.Semantic proximity Read ↗

Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic AgentSemantic proximity Read ↗

The human IL-7 receptor gene: deletions, polymorphisms and mutations.Semantic proximity Read ↗

Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients.Semantic proximity Read ↗

The Interleukin-7 Receptor Signaling Pathway and Its Perturbation in Immunodeficiency, Autoimmune Disease and Lymphoid Malignancy.Semantic proximity Read ↗

Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity.Semantic proximity Read ↗

Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk alleleSemantic proximity Read ↗

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.