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Interleukin-7 receptor α-chain haplotypes differentially affect soluble IL-7 receptor and IL-7 serum concentrations in children with type 1 diabetes.

Pediatric diabetes - 1 Aug 2018

Seyfarth Julia, Lundtoft Christian, Förtsch Katharina, Ahlert Heinz, Rosenbauer Joachim, Baechle Christina, Roden Michael, Holl Reinhard W, Mayatepek Ertan, Kummer Sebastian, Meissner Thomas, Jacobsen Marc

Abstract excerpt

BACKGROUND: Interleukin-7 receptor α-chain (IL7RA) haplotypes are associated with susceptibility for development of autoimmune diseases, including type 1 diabetes (T1D). A protective IL7RA haplotype which causes lower soluble IL-7R (sIL-7R) serum levels is hypothesized to restrict IL-7-availability for self-reactive T cells. Functional mechanisms affected by a risk-associated IL7RA haplotype are unknown. METHODS:...

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PMID: 29484785
DOI: 10.1111/pedi.12665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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