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Article

The human IL-7 receptor gene: deletions, polymorphisms and mutations.

Seminars in immunology - 1 Jun 2012

Mazzucchelli Renata I, Riva Agostino, Durum Scott K

Abstract excerpt

Most T cell subsets depend on IL-7 for survival. IL-7 binds to IL-7Rα and γc, initiating the signaling cascade. Deletion of IL-7Ra in humans has, for some time, been known to cause severe combined immunodeficiency. More recently, polymorphisms in IL-7R have been shown be a risk factor for a number of diseases that are autoimmune or involve excess immune and inflammatory responses including multiple sclerosis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Interleukin-7

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Identifiers

PMID: 22425228
DOI: 10.1016/j.smim.2012.02.007
PMCID: PMC6326362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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