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Article

Dysregulated TP53 Among PTSD Patients Leads to Downregulation of miRNA let-7a and Promotes an Inflammatory Th17 Phenotype.

Frontiers in immunology - 1 Jan 2021

Busbee Philip B, Bam Marpe, Yang Xiaoming, Abdulla Osama A, Zhou Juhua, Ginsberg Jay Paul Jack, Aiello Allison E, Uddin Monica, Nagarkatti Mitzi, Nagarkatti Prakash S

Abstract excerpt

Post-traumatic stress disorder (PTSD) is a psychiatric disorder and patients diagnosed with PTSD often express other comorbid health issues, particularly autoimmune and inflammatory disorders. Our previous reports investigating peripheral blood mononuclear cells (PBMCs) from PTSD patients showed that these patients exhibit an increased inflammatory T helper (Th) cell phenotype and widespread downregulation of...

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Share to Immunophenotyping
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35058939
DOI: 10.3389/fimmu.2021.815840
PMCID: PMC8763839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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