Article
Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype.
Molecular medicine (Cambridge, Mass.) - 14 Nov 2020
Bam Marpe, Yang Xiaoming, Busbee Brandon P, Aiello Allison E, Uddin Monica, Ginsberg Jay P, Galea Sandro, Nagarkatti Prakash S, Nagarkatti Mitzi
Abstract excerpt
BACKGROUND: Posttraumatic stress disorder (PTSD) is a psychiatric disorder accompanied by chronic peripheral inflammation. What triggers inflammation in PTSD is currently unclear. In the present study, we identified potential defects in signaling pathways in peripheral blood mononuclear cells (PBMCs) from individuals with PTSD. METHODS: RNAseq (5 samples each for controls and PTSD), ChIPseq (5 samples each) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.