Article
Engagement of the CXCL12-CXCR4 Axis in the Interaction of Endothelial Progenitor Cell and Smooth Muscle Cell to Promote Phenotype Control and Guard Vascular Homeostasis.
International journal of molecular sciences - 14 Jan 2022
Mause Sebastian F, Ritzel Elisabeth, Deck Annika, Vogt Felix, Liehn Elisa A
Abstract excerpt
Endothelial progenitor cells (EPCs) are involved in vascular repair and modulate properties of smooth muscle cells (SMCs) relevant for their contribution to neointima formation following injury. Considering the relevant role of the CXCL12-CXCR4 axis in vascular homeostasis and the potential of EPCs and SMCs to release CXCL12 and express CXCR4, we analyzed the engagement of the CXCL12-CXCR4 axis in various modes...
Topics
- Atherosclerosis
- Biomarkers
- Blood Vessels
- Cell Movement
- Cells, Cultured
- Chemokine CXCL12
- Endothelial Progenitor Cells
- Gene Expression
- Homeostasis
- Humans
- Myocytes, Smooth Muscle
- Neointima
- Phenotype