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Article

Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen.

Nature communications - 1 Jan 2013

Favrot Lorenza, Grzegorzewicz Anna E, Lajiness Daniel H, Marvin Rachel K, Boucau Julie, Isailovic Dragan, Jackson Mary, Ronning Donald R

Abstract excerpt

The increasing prevalence of drug-resistant tuberculosis highlights the need for identifying new antitubercular drugs that can treat these infections. The antigen 85 (Ag85) complex has emerged as an intriguing mycobacterial drug target due to its central role in synthesizing major components of the inner and outer leaflets of the mycobacterial outer membrane. Here we identify ebselen (EBS) as a potent inhibitor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24193546
DOI: 10.1038/ncomms3748
PMCID: PMC4049535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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