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Article

Cloning and Characterization of a Leucyl Aminopeptidase from Three Pathogenic Leishmania Species

1 Jul 2002

Abstract excerpt

Aminopeptidases are emerging as exciting novel drug targets and vaccine candidates in parasitic infections. In this study, we describe for the first time an aminopeptidase from three highly pathogenic Leishmania species. Intronless genes encoding a leucyl aminopeptidase (lap) were cloned from Leishmania amazonensis, Leishmania donovani, and Leishmania major, which encoded 60-kDa proteins that displayed homology...

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PMID: 12006595
DOI: 10.1074/jbc.m202779200

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