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Article

Genetic variants and increased expression of Parascaris equorum P-glycoprotein-11 in populations with decreased ivermectin susceptibility.

PloS one - 1 Jan 2013

Janssen I Jana I, Krücken Jürgen, Demeler Janina, Basiaga Marta, Kornaś Sławomir, von Samson-Himmelstjerna Georg

Abstract excerpt

Macrocyclic lactones (MLs) represent the major drug class for control of parasitic infections in humans and animals. However, recently reports of treatment failures became more frequent. In addition to human and ruminant parasitic nematodes this also is the case for the horse-nematode Parascaris equorum. Nevertheless, to date the molecular basis of ML resistance is still not understood. Unspecific resistance...

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Identifiers

PMID: 23637871
DOI: 10.1371/journal.pone.0061635
PMCID: PMC3634834

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