Article
Cyclipostins and cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo.
The Journal of biological chemistry - 23 Feb 2018
Viljoen Albertus, Richard Matthias, Nguyen Phuong Chi, Fourquet Patrick, Camoin Luc, Paudal Rishi R, Gnawali Giri R, Spilling Christopher D, Cavalier Jean-François, Canaan Stéphane, Blaise Mickael, Kremer Laurent
Abstract excerpt
An increasing prevalence of cases of drug-resistant tuberculosis requires the development of more efficacious chemotherapies. We previously reported the discovery of a new class of cyclipostins and cyclophostin (CyC) analogs exhibiting potent activity against Mycobacterium tuberculosis both in vitro and in infected macrophages. Competitive labeling/enrichment assays combined with MS have identified several serine...
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