Article
Sickle cell disease: a multigenic perspective of a single-gene disorder.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre - 1 Jan 2005
Kutlar Abdullah
Abstract excerpt
Although significant progress has been made in our understanding of sickle cell disease (SCD) and in the development of new therapies, many questions are still unanswered, and a cure remains elusive. This is particularly evident in the clinical heterogeneity of the disease. Studies have shown the importance of high hemoglobin F determinants and alpha-thalassemia as modifiers of disease severity, but these alone...
Topics
- Anemia, Sickle Cell
- Bilirubin
- Factor V
- Gene Expression Profiling
- Genetic Diseases, Inborn
- Genetic Markers
- Glucuronosyltransferase
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Mutation
- Polymorphism, Genetic