Magnesium sensing via LFA-1 regulates CD8+ T cell effector function.

doi:10.1016/j.cell.2021.12.039

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Article

Magnesium sensing via LFA-1 regulates CD8+ T cell effector function.

Cell - 17 Feb 2022

Lötscher Jonas, Martí I Líndez Adrià-Arnau, Kirchhammer Nicole, Cribioli Elisabetta, Giordano Attianese Greta Maria Paola, Trefny Marcel P, Lenz Markus, Rothschild Sacha I, Strati Paolo, Künzli Marco, Lotter Claudia, Schenk Susanne H, Dehio Philippe, Löliger Jordan, Litzler Ludivine, Schreiner David, Koch Victoria, Page Nicolas, Lee Dahye, Grählert Jasmin, Kuzmin Dmitry, Burgener Anne-Valérie, Merkler Doron, Pless Miklos, Balmer Maria L, Reith Walter, Huwyler Jörg, Irving Melita, King Carolyn G, Zippelius Alfred, Hess Christoph

Abstract excerpt

The relevance of extracellular magnesium in cellular immunity remains largely unknown. Here, we show that the co-stimulatory cell-surface molecule LFA-1 requires magnesium to adopt its active conformation on CD8+ T cells, thereby augmenting calcium flux, signal transduction, metabolic reprogramming, immune synapse formation, and, as a consequence, specific cytotoxicity. Accordingly, magnesium-sufficiency sensed...

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Identifiers

PMID: 35051368
DOI: 10.1016/j.cell.2021.12.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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