Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation.

doi:10.1038/s41598-023-33966-7

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Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation.

Scientific reports - 29 Apr 2023

Hanyuda Akiko, Goto Atsushi, Katagiri Ryoko, Koyanagi Yuriko N, Nakatochi Masahiro, Sutoh Yoichi, Nakano Shiori, Oze Isao, Ito Hidemi, Yamaji Taiki, Sawada Norie, Iwagami Masao, Kadota Aya, Koyama Teruhide, Katsuura-Kamano Sakurako, Ikezaki Hiroaki, Tanaka Keitaro, Takezaki Toshiro, Imoto Issei, Suzuki Midori, Momozawa Yukihide, Takeuchi Kenji, Narita Akira, Hozawa Atsushi, Kinoshita Kengo, Shimizu Atsushi, Tanno Kozo, Matsuo Keitaro, Tsugane Shoichiro, Wakai Kenji, Sasaki Makoto, Yamamoto Masayuki, Iwasaki Motoki

Abstract excerpt

Observational studies suggest that abnormal glucose metabolism and insulin resistance contribute to colorectal cancer; however, the causal association remains unknown, particularly in Asian populations. A two-sample Mendelian randomisation analysis was performed to determine the causal association between genetic variants associated with elevated fasting glucose, haemoglobin A1c (HbA1c), and fasting C-peptide and...

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PMID: 37120602
DOI: 10.1038/s41598-023-33966-7
PMCID: PMC10148817

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