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SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

25 Dec 2021

Abstract excerpt

Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human-induced...

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PMID: 35032430
DOI: 10.1016/j.stem.2021.12.010

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