Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

12 Nov 2021

Abstract excerpt

Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection remain poorly understood. Here, we combine SARS-CoV-2 variants with genome-edited kidney organoids and clinical data to investigate tropism, mechanism, and therapeutics. SARS-CoV-2 specifically infects organoid proximal tubules among diverse cell types. Infections produce replicating virus, apoptosis, and disrupted cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 and healthcare impacts
Share to Pancreatic and Hepatic Oncology Research
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34767537
DOI: 10.1172/jci.insight.154882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populationsPMID 34767537Read ↗

Kidney organoids reveal redundancy in viral entry pathways during ACE2-dependent SARS-CoV-2 infectionSemantic proximity Read ↗

Proteomic landscape of SARS-CoV-2– and MERS-CoV–infected primary human renal epithelial cellsSemantic proximity Read ↗

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoidsSemantic proximity Read ↗

Single-Cell RNA Sequencing of Urinary Cells Reveals Distinct Cellular Diversity in COVID-19–Associated AKISemantic proximity Read ↗

Temporal multi-omic analysis of COVID-19 in end-stage kidney diseaseSemantic proximity Read ↗

The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection.Semantic proximity Read ↗

The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infectionSemantic proximity Read ↗

Peripheral Transcriptomics in Acute and Long-Term Kidney Dysfunction in SARS-CoV2 InfectionSemantic proximity Read ↗

<strong>Molecular Basis of Kidney Defects in COVID-19 Patients</strong>Semantic proximity Read ↗

Mitigating Endemic COVID-19 Risks in Patients with Chronic Kidney Disease and Kidney Transplantation: A Narrative ReviewSemantic proximity Read ↗

Integrated multiomics implicates dysregulation of ECM and cell adhesion pathways as drivers of severe COVID-associated kidney injurySemantic proximity Read ↗

Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.