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Stem-like breast cancer cells in the activated state resist genetic stress via TGFBI-ZEB1

13 Jan 2022

Abstract excerpt

Abstract Breast cancer cells with stem-like properties are critical for tumor progression, yet much about these cells remains unknown. Here, we characterize a population of stem-like breast cancer cells expressing the integrin αvβ3 as transcriptionally related to activated stem/basal cells in the normal human mammary gland. An unbiased functional screen of genes unique to these cells identified the matrix protein...

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PMID: 35027548
DOI: 10.1038/s41523-021-00375-w

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