Study of the contribution of active defense mechanisms to ciprofloxacin tolerance in Escherichia coli growing at different rates.

doi:10.1007/s10482-021-01693-6

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Article

Study of the contribution of active defense mechanisms to ciprofloxacin tolerance in Escherichia coli growing at different rates.

Antonie van Leeuwenhoek - 1 Feb 2022

Smirnova Galina V, Tyulenev Aleksey V, Muzyka Nadezda G, Oktyabrsky Oleg N

Abstract excerpt

Using rpoS, tolC, ompF, and recA knockouts, we investigated their effect on the physiological response and lethality of ciprofloxacin in E. coli growing at different rates on glucose, succinate or acetate. We have shown that, regardless of the strain, the degree of changes in respiration, membrane potential, NAD+/NADH ratio, ATP and glutathione (GSH) strongly depends on the initial growth rate and the degree of...

Topics

Anti-Bacterial Agents
Ciprofloxacin
Defense Mechanisms
Escherichia coli
Escherichia coli Proteins
Mutation

Source

Open in PubMed

Identifiers

PMID: 35022927
DOI: 10.1007/s10482-021-01693-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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