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Article

A rugged yet easily navigable fitness landscape.

Science (New York, N.Y.) - 24 Nov 2023

Papkou Andrei, Garcia-Pastor Lucia, Escudero José Antonio, Wagner Andreas

Abstract excerpt

Fitness landscape theory predicts that rugged landscapes with multiple peaks impair Darwinian evolution, but experimental evidence is limited. In this study, we used genome editing to map the fitness of >260,000 genotypes of the key metabolic enzyme dihydrofolate reductase in the presence of the antibiotic trimethoprim, which targets this enzyme. The resulting landscape is highly rugged and harbors 514 fitness...

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Identifiers

PMID: 37995212
DOI: 10.1126/science.adh3860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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