Somatic loss of the remaining allele occurs approximately in half of CHEK2-driven breast cancers and is accompanied by a border-line increase of chromosomal instability.

doi:10.1007/s10549-022-06517-3

Article

Somatic loss of the remaining allele occurs approximately in half of CHEK2-driven breast cancers and is accompanied by a border-line increase of chromosomal instability.

Breast cancer research and treatment - 1 Apr 2022

Iyevleva Aglaya G, Aleksakhina Svetlana N, Sokolenko Anna P, Baskina Sofia V, Venina Aigul R, Anisimova Elena I, Bizin Ilya V, Ivantsov Alexandr O, Belysheva Yana V, Chernyakova Alexandra P, Togo Alexandr V, Imyanitov Evgeny N

Abstract excerpt

PURPOSE: Germline mutations in CHEK2 gene represent the second most frequent cause of hereditary breast cancer (BC) after BRCA1/2 lesions. This study aimed to identify the molecular characteristics of CHEK2-driven BCs. METHODS: Loss of heterozygosity (LOH) for the remaining CHEK2 allele was examined in 50 CHEK2-driven BCs using allele-specific PCR assays for the germline mutations and analysis of surrounding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Somatic loss of the remaining allele occurs approximately in half of CHEK2-driven breast cancers and is accompanied by a border-line increase of chromosomal instability.

Abstract excerpt

Topics

Related research