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Article

VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.

BMC biology - 29 May 2014

Baron Yorann, Pedrioli Patrick G, Tyagi Kshitiz, Johnson Clare, Wood Nicola T, Fountaine Daniel, Wightman Melanie, Alexandru Gabriela

Abstract excerpt

BACKGROUND: FAF1 is a ubiquitin-binding adaptor for the p97 ATPase and belongs to the UBA-UBX family of p97 cofactors. p97 converts the energy derived from ATP hydrolysis into conformational changes of the p97 hexamer, which allows the dissociation of its targets from cellular structures or from larger protein complexes to facilitate their ubiquitin-dependent degradation. VAPB and the related protein VAPA form...

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Source

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Identifiers

PMID: 24885147
DOI: 10.1186/1741-7007-12-39
PMCID: PMC4068158

Genes

VAPB
FAF1
RPN2
VAPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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