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Article

Structural basis of FFAT motif-mediated ER targeting.

Structure (London, England : 1993) - 1 Jul 2005

Kaiser Stephen E, Brickner Jason H, Reilein Amy R, Fenn Tim D, Walter Peter, Brunger Axel T

Abstract excerpt

The FFAT motif is a targeting signal responsible for localizing a number of proteins to the cytosolic surface of the endoplasmic reticulum (ER) and to the nuclear membrane. FFAT motifs bind to members of the highly conserved VAP protein family, which are tethered to the cytoplasmic face of the ER by a C-terminal transmembrane domain. We have solved crystal structures of the rat VAP-A MSP homology domain alone and...

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Identifiers

PMID: 16004875
DOI: 10.1016/j.str.2005.04.010

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