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Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast

10 Jan 2022

Abstract excerpt

Invasive micropapillary carcinoma (IMPC) has very high rates of lymphovascular invasion and lymph node metastasis and has been reported in several organs. However, the genomic mechanisms underlying its metastasis are unclear. Here, we perform whole-genome sequencing of tumor cell clusters from primary IMPC and paired axillary lymph node metastases. Cell clusters in multiple lymph node foci arise from a single...

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PMID: 35013309
DOI: 10.1038/s41467-021-27794-4

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