Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis

5 Oct 2021

Abstract excerpt

Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear. Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single cells from 15 paired samples of primary tumors and axillary lymph nodes. We identified nine cancer cell subclusters including CD44 + / ALDH2 + /ALDH6A1 + breast cancer stem cells (BCSCs), which had a copy-number variants profile similar to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34611125
DOI: 10.1038/s41389-021-00355-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasisPMID 34611125Read ↗

Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in breast cancer lymphatic node, bone, and brain metastasesSemantic proximity Read ↗

Single-cell transcriptomics provide insight into metastasis-related subsets of breast cancerSemantic proximity Read ↗

Single cell RNA sequencing for breast cancer: present and futureSemantic proximity Read ↗

The heterogeneity of breast cancer metastasis: a bioinformatics analysis utilizing single-cell RNA sequencing dataSemantic proximity Read ↗

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seqSemantic proximity Read ↗

Single-Cell RNA-Sequencing: Opening New Horizons for Breast Cancer ResearchSemantic proximity Read ↗

Single‐cell RNA sequencing in breast cancer: Understanding tumor heterogeneity and paving roads to individualized therapySemantic proximity Read ↗

Single-cell analyses reveal a simple multi-gene transcriptomic signature with predictive power in prognosis and therapy effectiveness in triple-negative breast cancerSemantic proximity Read ↗

Comprehensive analysis of immune evasion in breast cancer by single-cell RNA-seqSemantic proximity Read ↗

Recent progress and applications of single-cell sequencing technology in breast cancerSemantic proximity Read ↗

Pan-cancer classification of single cells in the tumour microenvironmentSemantic proximity Read ↗

Integrative analyses of scRNA-seq and scATAC-seq reveal CXCL14 as a key regulator of lymph node metastasis in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.