Clonal evolutionary analysis reveals patterns of malignant transformation of Intraductal Papillary Mucinous Neoplasms of the pancreas.

doi:10.1038/s41467-026-69762-w

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Article

Clonal evolutionary analysis reveals patterns of malignant transformation of Intraductal Papillary Mucinous Neoplasms of the pancreas.

Nature communications - 4 Mar 2026

Pea Antonio, He Xiaotong, Upstill-Goddard Rosie, Luchini Claudio, Schubert Santana Leonor Patricia, Dreyer Stephan, Duthie Fraser, Jamieson Nigel B, McKay Colin J, Dickson Euan J, Pulvirenti Alessandra, Rebus Selma, Piccoli Paola, Sperandio Nicola, Lawlor Rita T, Milella Michele, Froeling Fieke E M, Salvia Roberto, Scarpa Aldo, Biankin Andrew V, Wedge David C, Chang David K

Abstract excerpt

Intraductal papillary mucinous neoplasms (IPMNs) are critical precursors to pancreatic ductal adenocarcinoma, a highly lethal cancer characterized by late detection and rapid progression. Here we integrate multi-region whole-genome and transcriptome sequencing to trace the evolution of IPMN, constructing detailed phylogenetic trees to provide insights into subclonal architectures and progression pathways. Our...

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Identifiers

PMID: 41775703
DOI: 10.1038/s41467-026-69762-w
PMCID: PMC13076896

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