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Article

Exploration of a Polygenic Risk Score for Alcohol Consumption: A Longitudinal Analysis from the ALSPAC Cohort.

PloS one - 1 Jan 2016

Taylor Michelle, Simpkin Andrew J, Haycock Philip C, Dudbridge Frank, Zuccolo Luisa

Abstract excerpt

BACKGROUND: Uncertainty remains about the true extent by which alcohol consumption causes a number of health outcomes. Genetic variants, or combinations of variants built into a polygenic risk score (PGRS), can be used in an instrumental variable framework to assess causality between a phenotype and disease outcome of interest, a method known as Mendelian randomisation (MR). We aimed to identify genetic variants...

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Identifiers

PMID: 27902751
DOI: 10.1371/journal.pone.0167360
PMCID: PMC5130278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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