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The (pro)renin receptor: a novel biomarker and potential therapeutic target for various cancers

6 Mar 2020

Abstract excerpt

BACKGROUND: The (pro) renin receptor ((P)RR) plays important roles in various pathways, such as the Wnt/β-catenin, renin-angiotensin system (RAS), MAPK/ERK and PI3K/AKT/mTOR pathways, that are involved in a wide range of physiological and pathological processes incorporating the tumorigenesis. However, our knowledge about (P) RR was mostly limited to its roles in cardiovascular and renal physiological functions...

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PMID: 32143717
DOI: 10.1186/s12964-020-0531-3

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