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Article

The Role of the (Pro)renin Receptor in Hypertensive Disease

18 Apr 2015

Abstract excerpt

Tissue angiotensin generation depends on the uptake of circulating (kidney-derived) renin and/or its precursor prorenin (together denoted as (pro)renin). Since tissue renin levels are usually higher than expected based upon the amount of (renin-containing) blood in tissue, an active uptake mechanism has been proposed. The (pro)renin receptor ((P)RR), discovered in 2002, appeared a promising candidate, although...

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Share to Hormonal Regulation and Hypertension
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PMID: 25890829
DOI: 10.1093/ajh/hpv045

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