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Article

MicroRNA 630 Represses NANOG Expression through Transcriptional and Post-Transcriptional Regulation in Human Embryonal Carcinoma Cells.

International journal of molecular sciences - 21 Dec 2021

Chu Wing-Keung, Hung Li-Man, Hou Chun-Wei, Chen Jan-Kan

Abstract excerpt

The pluripotent transcription factor NANOG is essential for maintaining embryonic stem cells and driving tumorigenesis. We previously showed that PKC activity is involved in the regulation of NANOG expression. To explore the possible involvement of microRNAs in regulating the expression of key pluripotency factors, we performed a genome-wide analysis of microRNA expression in the embryonal carcinoma cell line...

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Identifiers

PMID: 35008480
DOI: 10.3390/ijms23010046
PMCID: PMC8744645

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