Article
A Quantitative Systems Approach to Define Novel Effects of Tumour p53 Mutations on Binding Oncoprotein MDM2.
International journal of molecular sciences - 21 Dec 2021
Fuentes Manuel, Srivastava Sanjeeva, Gronenborn Angela M, LaBaer Joshua
Abstract excerpt
Understanding transient protein interactions biochemically at the proteome scale remains a long-standing challenge. Current tools developed to study protein interactions in high-throughput measure stable protein complexes and provide binary readouts; they do not elucidate dynamic and weak protein interactions in a proteome. The majority of protein interactions are transient and cover a wide range of affinities....
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