Article

Novel sensor-integrated proteome on chip (SPOC) platform with thousands of folded proteins on a 1.5 sq-cm biosensor chip to enable high-throughput real-time label-free screening for kinetic analysis

2024-01-24

Abstract excerpt

An automated proteomic platform for producing and screening an array of functional proteins on biosensor surfaces was developed to address the challenges of measuring proteomic interaction kinetics in high throughput (HTP). This technology is termed Sensor-Integrated Proteome On Chip (SPOC®) which involves in-situ cell-free protein expression in nano-liter volume wells (nanowells) directly from rapidly customizab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c5d963c-95e6-5f07-bbea-399552a1c84a
DOI: 10.1101/2024.01.23.575909

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel sensor-integrated proteome on chip (SPOC) platform with thousands of folded proteins on a 1.5 sq-cm biosensor chip to enable high-throughput real-time label-free screening for kinetic analysisDOI 10.1101/2024.01.23.575909Read

An approach to produce thousands of single-chain antibody variants on a SPR biosensor chip for measuring target binding kinetics and for deep characterization of antibody paratopesSemantic proximity Read

Real-time dynamic single-molecule protein sequencing on an integrated semiconductor deviceSemantic proximity Read

An Automated End-to-End Workflow for Production of Secreted Proteins in Transfected Mammalian CellsSemantic proximity Read

Cell-free immuno-profiling on a genetically programmed biochipSemantic proximity Read

Multiplex mapping of protein-protein interaction interfacesSemantic proximity Read

A Quantitative Systems Approach to Define Novel Effects of Tumour p53 Mutations on Binding Oncoprotein MDM2.Semantic proximity Read

High-throughput protein binder discovery by rapid in vivo selectionSemantic proximity Read

Expanding High-Fidelity Multiplexing in Ultrasensitive Single-Molecule Protein Detection via Proximity BarcodingSemantic proximity Read

A modular cell-free protein biosensor platform using split T7 RNA polymeraseSemantic proximity Read

Protein biochips: A new and versatile platform technology for molecular medicineSemantic proximity Read

High-throughput analysis system of interaction kinetics for data-driven antibody designSemantic proximity Read

Protein MicroarraysSemantic proximity Read