Article
Mutation Analysis of Radioresistant Early-Stage Cervical Cancer.
International journal of molecular sciences - 21 Dec 2021
Oike Tae, Sekiguchi Yoshihito, Yoshimoto Yuya, Oike Takahiro, Ando Ken, Gu Wenchao, Sasaki Yasushi, Tokino Takashi, Iwase Akira, Ohno Tatsuya
Abstract excerpt
Radiotherapy is a definitive treatment for early-stage cervical cancer; however, a subset of this disease recurs locally, necessitating establishment of predictive biomarkers and treatment strategies. To address this issue, we performed gene panel-based sequencing of 18 stage IB cervical cancers treated with definitive radiotherapy, including two cases of local recurrence, followed by in vitro and in silico...
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