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Article

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer.

Molecular oncology - 1 Mar 2026

Sambath Janani, George Irene A, Manda Srikanth S, Ariyannur Prasanth, Dhawale Ekta R, Kommu Raja Sekhar, Datar Rajan, Patil Darshana, Trivedi Vinita, Singh Manisha, Prabhash Kumar, Limaye Sewanti, Chauhan Richa, Kumar Prashant

Abstract excerpt

Cervical cancer is highly prevalent in India, with most cases being diagnosed at advanced stages. Despite the standard concurrent chemoradiotherapy (CCRT), 30-40% of patients' experience treatment failure, underscoring the need for improved therapeutic strategies. Understanding resistance mechanisms and identifying predictive biomarkers are crucial to improve treatment efficacy and enable personalized medicine....

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Topics

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Share to Chemoradiotherapy
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to KMT2D gene

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Share to Uterine Cervical Neoplasms

Source

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Identifiers

PMID: 41586744
DOI: 10.1002/1878-0261.70108
PMCID: PMC13042866

Genes

EGFR
STK11
STX3
EMILIN2
KMT2D
LBP
NQO2
PIK3CA
SERPINB7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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