Article
Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion.
American journal of physiology. Renal physiology - 1 Nov 2010
Bishop Jesse M, Verlander Jill W, Lee Hyun-Wook, Nelson Raoul D, Weiner Arthur J, Handlogten Mary E, Weiner I David
Abstract excerpt
Rh B glycoprotein (Rhbg) is a member of the Rh glycoprotein family of ammonia transporters. In the current study, we examine Rhbg's role in basal and acidosis-stimulated acid-base homeostasis. Metabolic acidosis induced by HCl administration increased Rhbg expression in both the cortex and outer medulla. To test the functional significance of increased Rhbg expression, we used a Cre-loxP approach to generate mice...
Topics
- Acidosis
- Acids
- Alleles
- Ammonia
- Animals
- Bicarbonates
- Blotting, Western
- Diet
- Electrolytes
- Gene Deletion
- Gene Expression Regulation, Enzymologic