Article

Kidney-specific <i>Wdr72</i> deletion leads to incomplete distal renal tubular acidosis through impaired V-ATPase B1 subunit localization

2025-10-29

Abstract excerpt

<h4>Background</h4> Distal renal tubular acidosis (dRTA) is a rare kidney disorder characterized by impaired urinary acidification due to defective proton secretion in type A intercalated cells of the collecting duct. Recently, pathogenic variants in the human gene encoding the WD Repeat Domain 72 protein ( WDR72 ) have been reported in patients with dRTA, yet the physiological role of WDR72 in the kidney remai...

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Literature Corpus work: ff03d788-1be4-5f70-ad81-a9e5bbdea1d5
DOI: 10.1101/2025.10.29.684588

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