Article
Ribozyme Mutagenic Evolution: Mechanisms of Survival.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life - 1 Dec 2021
Diaz Arenas Carolina, Ardaševa Aleksandra, Miller Jonathan, Mikheyev Alexander S, Yokobayashi Yohei
Abstract excerpt
Primeval populations replicating at high error rates required a mechanism to overcome the accumulation of mutations and information deterioration. Known strategies to overcome mutation pressures include RNA processivity, epistasis, selection, and quasispecies. We investigated the mechanism by which small molecular ribozyme populations can survive under high error rates by propagating several lineages under...
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