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Article

Real ribozymes suggest a relaxed error threshold.

Nature genetics - 1 Sept 2005

Kun Adám, Santos Mauro, Szathmáry Eörs

Abstract excerpt

The error threshold for replication, the critical copying fidelity below which the fittest genotype deterministically disappears, limits the length of the genome that can be maintained by selection. Primordial replication must have been error-prone, and so early replicators are thought to have been necessarily short. The error threshold also depends on the fitness landscape. In an RNA world, many neutral and...

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PMID: 16127452
DOI: 10.1038/ng1621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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